PRP Use For Infertility; Getting the Uterus Ready!

Getting pregnant has several critical steps. Even couples who are helped to ovulate, have a good sperm count, and time their conception perfectly may not conceive if the lining of the uterus is not healthy enough for implantation. Preparing the uterine lining has mostly been done with estrogen treatments. It's also important to be sure you don't have other problems with the uterus, including scaring, or infection, or polyps, but again, in the absence of these some women do not conceive. Hundreds of genes that are differently expressed at the time of implantation, as well as the immune system, play an active role during embryo-endometrium interaction Other than estrogen medicines like silenafil, aspirin and heparin have been tried with varying success. The lining is so complex that it takes the coordinated efforts of many hormones and the synchronization of literally hundreds of genes to establish a uterus with the proper place for implantation so that coordination between embryo and endometrium can proceed and a pregnancy implant A new way to prepare the uterus with PRP therapy has been studied with some promising success.
Platelet Rich Plasma (PRP) therapy is one of the most versatile treatments in medicine and for aesthetic uses. It’s first studied medical therapeutic use was for wound healing, and it is ideally suited to heal the endometrium as well. The PRP therapy contains growth factors, adhesive proteins, clotting factors as well other important healing compounds, and compounds that help our tissues stay healthy. PRP components help us fight both inflammation and infection that may be the cause of poor implantation. PRP also stimulates new nerve formation and new blood vessel formation. The growth factors act as chemical messengers signaling the appearance of new cells. When these factors work on a tissue, stem cell production is triggered. After stem cells are produced other cells, in this case the endometrial, or uterine lining cells. The scientific definition of concentrated platelet rich plasma must meet the level of 1 million platelets per 5 cc of plasma. It is important to have this concentration in order to be able to get effective healing and treatment response. Inadequate concentration during the preparation is responsible for some reports of less than satisfying results from therapy. So it is important to be treated by PRP therapy prepared by the best technology. The platelets have a number of proteins in addition to the growth factors which are released from the platelets when they are activated. The release of the important compounds in sufficient numbers can affect the result as well. There is a direct proportion of numbers of cells produced in the treatment area directly in relationship to the concentration of the PRP. 5 x PRP concentration increases cell production of over 200% in certain parts of the body, and in active tissue like the endometrium this may be more. It may be that the PRP could enhance the effects of the other medicines like estradiol. It is used by instilling it into the uterus with a catheter. The risks are relatively few from PRP treatment, and is regarded as something to try prior to going to a surrogate. For those interested in PRP therapy contact Women's Health Practice, 217-356-3736.

Passing Your Uterine Lining, Menstrual Period Norms

Decidual Cast Periods can be fairly easy, passing some tissue at a time, or off can come the whole lining in one piece called a decidual cast. Generally the lining of the uterus is only 6-8 mm thick at the time of the menstrual period, and it is shed gradually, a few cells at a time. The decidual cast is when the entire lining passes spontaneously. It's not uncommon, but it usually both uncomfortable, and alarming to some. But us women are designed to have some sort of periods Or Not? We have to pass tissue each month. Or Not? Are they good for us? Or Not? Do we want them? Or Not? Is this something that is individual? Or Not? It's a complex topic that I will be discussing a lot over my time in this blog. So lets start with basics: How much do we bleed and what are we loosing, and just what was this that the patient passed? And another basic: track your periods, and the Women's Health Practice site http://www.womenshealthpractice.com/media/pdf/menstrual_chart.pdf you...

Post-Endometrial Ablation Syndrome

If you have had an endometrial ablation and have developed symptoms of pelvic pain you might have post endometrial ablation syndrome. What is post-endometrial ablation syndrome? It is a constellation of symptoms due to entrapped blood or tissue within a uterus that has previously undergone an endometrial ablation. We are able to diagnose this at Women's Health Practic e but occasionally other conditions are causing similar symptoms. Other complications of endometrial ablation include pregnancy, risks from pre-existing conditions such as a polyp or fibroid, an infection of the uterus, or a pregnancy. If you have had a tubal ligation then it is possible that the condition could be post-ablation tubal sterilization syndrome. The ablation procedure is designed to destroy all lining tissue, but in fact there is no way to confirm the completeness of the ablation. It is thought that either residual or regrowth of the tissue is producing the symptoms of post-endometrial ablation syndrom...

You Have an IUD: But a Positive Pregnancy Test

Fortunately IUD pregnancy failures are rare. But if you have an IUD for contraception, and you get a positive pregnancy test, you probably ask yourself, what next? Well, make your gyno appointment promptly, this is a condition that is not typically an emergency, but it can be and it’s not handled over the phone or on a blog, or through self diagnosis! That being said, some researchers from University of Texas Southwestern Medical Center in Dallas decided to look back at over 4100 women who had IUDs and of those 42 cases who became pregnant in their institution, over about a year period of time, to help understand what these women could expect when they got to their gyno and what actually happened to their pregnancies. Accurate pregnancy diagnosis, pelvic examination, and pelvic ultrasound were the cornerstones of the evaluations. They had very specific ways they looked at their ultrasound to prove there was no pregnancy in the fallopian tube, or partially in the fallopian tube...

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