Read all the newest reports on Estrogen use in Menopause very carefully. It's confusing, perhaps contradictory to what we've said before, and you can't just flip between blog posts and get a consistent answer! The newest information from the WHI has been released to members of the The North American
Menopause Society (NAMS) specifically about the new paperr entitled “Health outcomes after
stopping conjugated equine estrogens among postmenopausal women with prior
hysterectomy: a randomized controlled trial.” It was published today, April 6,
2011, in the Journal of the
American Medical Association. For your convenience both the article1 and the accompanying editorial2 are linked here and referenced below. In this study young women, meaning those who got hormone therapy as they transitioned through menopause and were just given conjugated equine
estrogens (CEE) hadless invasive breast
cancer and less coronary heart disease (CHD),
all-cause mortality than older women.
These are usually women who do not have a uterus, and were ths not given provera or progesterone and had different timing of estrogen. So we think there is both a timing factor and a possible formulation factor to hormone therapy in menopause.
The actual article are results of
the Women’s Health Initiative Estrogen-Alone Trial, reflecting a median of 6
years of treatment and an average of 10.7 years of follow-up. The long-term follow-up and post-stopping findings for this trial
have not been previously reported. The authors examined health outcomes in
10,739 women with prior hysterectomy, comparing those randomized to receive CEE
treatment versus placebo.
For the
overall study population, there was a significantly (23%) reduced risk of invasive breast cancer among
women randomized to CEE versus placebo over the 10.7 years of follow-up. However, younger women (ages
50-59 at enrollment) tended to have much more favorable outcomes on CEE in the areas of heart disease and overall mortality. For other results, please refer to the article itself. For information on whether this can change how you should take hormone therapy: Gab with your Gyno.
1LaCroix AZ, Chlebowski RT, Manson JE et al.
Health outcomes after stopping conjugated equine estrogens among postmenopausal
women with prior hysterectomy: a randomized controlled trial. JAMA
2011;305:1305-1314.
That sounds cool, because women get depressed when they come to know about this. So it's better to be with precaution.
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